Nature & Science publications



"The" ProteoPlex Paper:

Chari, A.; Haselbach, D.; Kirves, J. M.; Ohmer, J.; Paknia, E.; Fischer, N.; Ganichkin, O.; Moller, V.; Frye, J. J.; Petzold, G. et al.: ProteoPlex: Stability optimization of macromolecular complexes by sparse-matrix screening of chemical space. Nature Methods 12 (9), S. 859-865 (2015)




ProteoPlex in a wider context:

Renaud, J.-P.; Chari, A.; Ciferri, C.; Liu, W.; Rémigy, H.-W.; Stark, H.; Wiesmann, C.: Cryo-EM in drug discovery: achievements, limitations and prospects. Nature Reviews Drug Discovery, 2018/06/08/online (2018)


  See particuarly p.9 "Optimized sample preparation"



Specific examples for sample optimization:

Schrader, J.; Henneberg, F.; Mata, R.; Tittmann, K.; Schneider, T.; Stark, H.; Bourenkov, G.; Chari, A.: The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design. Science Research Report, Vol. 353, Issue 6299, pp. 594-598 (2016)



Haselbach, D.; Schrader, J.; Lambrecht, F.; Henneberg, F.; Chari, A.;Stark, H.: Long-range allosteric regulation of the human 26S proteasome by 20S proteasome-targeting cancer drugs. Nat. Commun. 8, 15578 doi: 10.1038/ncomms15578 (2017)



Sejwal, K.; Chami, M.; Rémigy, F.; Vancraenenbroeck, R.; Sibran, W.; Sütterlin, R.; Baumgartner, P.; McLeod, R.; Chartier-Harlin, M.-C.; Baekelandt, V.; Stahlberg, H. & Taymans, J.-M.: Cryo-EM analysis of homodimeric full-length LRRK2 and LRRK1 protein complexes. Nature Scientific Reports 7, Article number: 8667 (2017)


  Please note: without ProteoPlex there would have been no EM data at all for one of the complexes





Joint press release with NovAliX, 27th March 2018

"NovAliX enters into cooperation agreement with ProteoPlex"

Press release EMBL,

4th Aug 2016:

"Every atom counts"

EMBL Science,

8th Aug 2016:

"Blocking the cell's waste disposal unit"