Nature & Science publications

 

 

Chari, A.; Haselbach, D.; Kirves, J. M.; Ohmer, J.; Paknia, E.; Fischer, N.; Ganichkin, O.; Moller, V.; Frye, J. J.; Petzold, G. et al.: ProteoPlex: Stability optimization of macromolecular complexes by sparse-matrix screening of chemical space. Nature Methods 12 (9), S. 859-865 (2015)

  Download: http://www.nature.com/nmeth/journal/v12/n9/full/nmeth.3493.html

 

 

Schrader, J.; Henneberg, F.; Mata, R.; Tittmann, K.; Schneider, T.; Stark, H.; Bourenkov, G.; Chari, A.: The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design. Science Research Report, Vol. 353, Issue 6299, pp. 594-598 (2016)

  Download: http://science.sciencemag.org/content/353/6299/594

 

 

Haselbach, D.; Schrader, J.; Lambrecht, F.; Henneberg, F.; Chari, A.;Stark, H.: Long-range allosteric regulation of the human 26S proteasome by 20S proteasome-targeting cancer drugs. Nat. Commun. 8, 15578 doi: 10.1038/ncomms15578 (2017)

  Download: https://www.nature.com/articles/ncomms15578

 

 

Sejwal, K.; Chami, M.; Rémigy, F.; Vancraenenbroeck, R.; Sibran, W.; Sütterlin, R.; Baumgartner, P.; McLeod, R.; Chartier-Harlin, M.-C.; Baekelandt, V.; Stahlberg, H. & Taymans, J.-M.: Cryo-EM analysis of homodimeric full-length LRRK2 and LRRK1 protein complexes. Nature Scientific Reports 7, Article number: 8667 (2017)

  Download: https://www.nature.com/articles/s41598

  Please note: without ProteoPlex there would have been no EM data at all for one of the complexes

 

 

Renaud, J.-P.; Chari, A.; Ciferri, C.; Liu, W.; Rémigy, H.-W.; Stark, H.; Wiesmann, C.: Cryo-EM in drug discovery: achievements, limitations and prospects. Nature Reviews Drug Discovery, 2018/06/08/online (2018)

  Download: https://www.nature.com/articles/nrd.2018.77

  See particuarly p.9 "Optimized sample preparation"

  

 

 

 

 

Joint press release with NovAliX, 27th March 2018

"NovAliX enters into cooperation agreement with ProteoPlex"

Press release EMBL,

4th Aug 2016:

"Every atom counts"

EMBL Science,

8th Aug 2016:

"Blocking the cell's waste disposal unit"