3 - Ultra high quality proteins

 

Value proposition / USP:

Due to patented protein preparation methods, our human 20S proteasomes have unmatched characteristics:

  • 10-fold increase in specific activity, compared to what has been published to-date
  • Regularly crystallize and diffract to below 2.2A, best resolution 1.8A

 

Success story (example):

Previous inhibitors of the 20S proteasome were lacking sufficient resolution of electron density in the proteasome's active site to unequivocally model the inhibited state in atomic detail. Our new crystal structures of the 20S proteasome with achieved resolutions of 1.8 to 2.2A provided this insight and allowed to propose a new chemical mechanism for the inhibition of the 20S proteasome.

 

Business model:

Sell proteins

 

Datasheet Human 20S Proteasome - ProteoPlex
20170117 data sheet ProteoPlex 20S Prote[...]
PDF-Dokument [72.2 KB]

 

Perspective:

Extend portfolio (same USP as above):

  • Human 26S/30S proteasome
  • Human immunoproteasome
  • Fatty acid synthase
  • Pre-mix of crystallization and stabilization conditions

 

Suggested further reading:

Schrader, J.; Henneberg, F.; Mata, R.; Tittmann, K.; Schneider, T.; Stark, H.; Bourenkov, G.; Chari, A.: The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design. Science Research Report, Vol. 353, Issue 6299, pp. 594-598 (2016)

 

Download: http://science.sciencemag.org/content/353/6299/594

 

Defensibility:

Exclusive delivery contract with Max-Planck

 

Potential collaborators:

  • CROs that do complex structures for pharmaceutical companies
  • Pharmaceutical companies that work with respective targets

 

Our structures in the EMBD: