- Pick the high hanging fruit -
Specimen improvement for structural analysis
by EM and X-ray with ProteoPlex MacroDSF
ProteoPlex MacroDSF technology can greatly
improve sample quality for structural
studies of proteins by EM and X-ray.
Structural biology will shift more and
more towards challenging structures.
The Protein Data Bank (PDB) currently
holds 120,000 protein entries, but less
than 1% are multi-domain proteins
- because they are difficult to do.
A multitude of structural studies have
been performed on individual proteins.
But most proteins form a network of
interactions with other proteins and many
are components of large complexes in-vivo.
The understanding of this protein complex
formation and function is still very limited,
because most protein complexes pose high
challenges in terms of preparation and handling.
Obtaining high-quality structural information
of complexes therefore needs sophisticated
methods and know-how.
This enables scientists to create an optimized,
robust pipeline for the purification and
crystallization of these proteins that can
generate large quantities of ultra-high-quality
crystals that routinely diffract to high resolution.
ProteoPlex MacroDSF helps you to grab
the high hanging fruit by boosting your
sample quality to unprecedented levels,
ensuring that your research stays
ahead of the curve.
All ProteoPlex technologies are exclusively licensed from
Joint press release with NovAliX, 27th March 2018
Press release MPG,
7th Nov 2017:
Press release EMBL,
4th Aug 2016:
8th Aug 2016: