Pick the high-hanging fruit

ProteoPlex's toolkit for structural biology of macromolecules

 

Structural biology will shift more and more towards challenging structures. The Protein Data Bank (PDB) currently holds 120,000 protein entries, but less than 1% are multi-domain proteins - because they are difficult to do.

 

A multitude of structural studies have been performed on individual proteins. But most proteins form a network of interactions with other proteins and many are components of large complexes in-vivo. The understanding of this protein complex formation and function is still very limited, because most protein complexes pose high challenges in terms of preparation and handling.

 

Obtaining high-quality structural information of complexes therefore necessitates sophisticated analytical methods and know-how in order to create an optimized, robust pipeline for the purification and crystallization of these proteins that can generate large quantities of ultra-high-quality crystals that routinely diffract to high resolution.

 

All four ProteoPlex products help tackling these challenges. They allow users to better understand structure and function of macromolecular complexes that play fundamental roles within the cell and often are medically relevant.

 

 

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